Relentless attacks against al-Qaida in the Pakistan tribal region appear to have driven Osama bin Laden and other top leaders deeper into hiding, CIA Director Leon Panetta says.

A package of tax breaks and highway spending cleared Congress, the first of what Democrats hope will be several efforts to bring down the 9.7 percent unemployment rate.

President Barack Obama said Wednesday that he does not oppose plans by House Democrats to pass his much-challenged health care overhaul without a direct vote.

Some workers soon will be able to pick a new type of insurance that offers free care for some illnesses, such as diabetes or depression, but requires hefty extra fees for treatments deemed overused.

Dancing Dubliners and New York City parade goers wearing kilts and green body paint led the world in celebrating St. Patrick on Wednesday along sun-warmed parade routes in gatherings large and small.

Joseph Casias has been legally using medical marijuana to deal with the gnawing pain caused by sinus cancer and an inoperable brain tumor. But then was fired for it.

Little Tikes' Cozy Coupe is among the most unusual items in the toy industry today: A product that is manufactured in the United States.

A missing persons case involving a Memphis mother reaches shocking end Wednesday after the woman's body is discovered stuffed inside a bed frame in a motel, police said.

The rising Red River passes the "major flood" stage, as thousands of volunteers, many students, as well as National Guard troops worked furiously to fortify Fargo and Moorhead.

A Pakistani court formally charged five Americans of plotting terrorism in the country, in a case that has raised alarm over the danger posed by militants using the Internet.

Wal-Mart Stores Inc. officials are reviewing security tapes to try to determine who used a southern New Jersey store's public-address system to tell "all black people" to leave.

The Vienna Boys' Choir said it has heard from eight possible abuse victims following an initial report of allegations last week.

Producer prices fell more steeply than expected as energy costs tumbled, giving the Fed leeway to hold interest rates exceptionally low for an extended period as it has promised.

Voters in the village of Seneca Falls, the upstate New York birthplace of the women's rights movement, have approved a proposal to dissolve their government and merge into the surrounding town.

A man who was listening to his iPod while jogging on a South Carolina beach likely never saw or heard the small plane that hit him from behind and killed him, authorities say.

Two Emirates airlines cabin crew have been ordered jailed for three months in Dubai over sexually explicit text messages, the latest in a string of indecency cases against foreigners, a newspaper reported Wednesday.

Families with twins or triplets are more likely to separate due to the financial burdens involved, according to a survey on Wednesday.

On a night where nobody was terrible enough to be the obvious choice to go home, the question becomes: Who was memorable enough to rest easy?

Actress abruptly pulls out of the London premiere of “The Blind Side,” giving some credibility to reports that her marriage to Jesse James is in trouble.

Detroit will close 44 public schools and a support building in June due to budget issues and declining enrollment.

Horses not only remember people who have treated them well, they also understand words better than expected, research shows.

A drywall contractor and father, a petite woman who cared for the elderly, a U.S. military officer: The alarming thing about a string of terror suspects is they are all Americans.

Armenians living in Turkey without citizenship could be ordered to leave after U.S. and Swedish lawmakers vote to define 90-year-old killings of Armenians as genocide.

A woman championed as the Obama administration's emblem for health care reform does not have to choose between her home and her health, Ohio health officials say.

A 67-year-old country musician from Montana who spent four days in his car stuck on a remote mountain road said he wrote a goodbye letter and was preparing himself for death when he was rescued.